CCA tRNA nucleotidyltransferase 1, mitochondrial

Definition:

[Isoform 1]: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates.; [Isoform 2]: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro).

References:

[1]. Esther Lizano, et al. A splice variant of the human CCA-adding enzyme with modified activity. J Mol Biol. 2007 Mar 2;366(4):1258-65. [Content Brief]

[2]. T Nagaike, et al. Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases. J Biol Chem. 2001 Oct 26;276(43):40041-9. [Content Brief]

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