CCHC-type zinc finger nucleic acid binding protein
Definition:
Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression. Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner (By similarity).; [Isoform 1]: Binds G-rich elements in target mRNA coding sequences. Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs.; [Isoform 2]: Binds to RNA.; [Isoform 4]: Binds to RNA.; [Isoform 5]: Binds to RNA.; [Isoform 6]: Binds to RNA.; [Isoform 8]: Binds to RNA.
References:
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[1]. T B Rajavashisth, et al. Identification of a zinc finger protein that binds to the sterol regulatory element. Science. 1989 Aug 11;245(4918):640-3. [Content Brief]
[2]. Daniel Benhalevy, et al. The Human CCHC-type Zinc Finger Nucleic Acid-Binding Protein Binds G-Rich Elements in Target mRNA Coding Sequences and Promotes Translation. Cell Rep. 2017 Mar 21;18(12):2979-2990. [Content Brief]
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