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CD166 antigen

Definition:

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6. Mediates homotypic interactions with cells that express ALCAM. Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation. Required for normal hematopoietic stem cell engraftment in the bone marrow. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity).; [Isoform 3]: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation.

References:

[1]. Maria Iolyeva, et al. Novel role for ALCAM in lymphatic network formation and function. FASEB J. 2013 Mar;27(3):978-90. [Content Brief]

[2]. Namir J Hassan, et al. Frontline: Optimal T cell activation requires the engagement of CD6 and CD166. Eur J Immunol. 2004 Apr;34(4):930-40. [Content Brief]

[3]. Cristina Escoda-Ferran, et al. Modulation of CD6 function through interaction with Galectin-1 and -3. FEBS Lett. 2014 Aug 25;588(17):2805-13. [Content Brief]

[4]. Idoia Gimferrer, et al. Relevance of CD6-mediated interactions in T cell activation and proliferation. J Immunol. 2004 Aug 15;173(4):2262-70. [Content Brief]

[5]. Zheng Xu, et al. ILT3.Fc-CD166 Interaction Induces Inactivation of p70 S6 Kinase and Inhibits Tumor Cell Growth. J Immunol. 2018 Feb 1;200(3):1207-1219. [Content Brief]

[6]. Brahmananda Reddy Chitteti, et al. CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche. Blood. 2014 Jul 24;124(4):519-29. [Content Brief]

[7]. M A Bowen, et al. Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. J Exp Med. 1995 Jun 1;181(6):2213-20. [Content Brief]

[8]. Aukje W Zimmerman, et al. Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells. Blood. 2006 Apr 15;107(8):3212-20. [Content Brief]

[9]. Koji Ikeda, et al. Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function. J Biol Chem. 2004 Dec 31;279(53):55315-23. [Content Brief]

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