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CDKN2A-interacting protein

Definition:

Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.

References:

[1]. Md Kamrul Hasan, et al. Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control. Biochem J. 2004 Jun 15;380(Pt 3):605-10. [Content Brief]

[2]. Caroline T Cheung, et al. Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling. J Biol Chem. 2014 Jun 27;289(26):18258-69. [Content Brief]

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