Cell division cycle 7-related protein kinase

Definition:

Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN.

References:

[1]. A Montagnoli, et al. Drf1, a novel regulatory subunit for human Cdc7 kinase. EMBO J. 2002 Jun 17;21(12):3171-81. [Content Brief]

[2]. Chi-Chun Yang, et al. Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells. Nat Commun. 2016 Jul 12;7:12135. [Content Brief]

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