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Ceramide kinase

Definition:

Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Shows a greater preference for D-erythro isomer of ceramides. Binds phosphoinositides.

References:

[1]. Anthony S Don, et al. A lipid binding domain in sphingosine kinase 2. Biochem Biophys Res Commun. 2009 Feb 27;380(1):87-92. [Content Brief]

[2]. Masako Sugiura, et al. Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. J Biol Chem. 2002 Jun 28;277(26):23294-300. [Content Brief]

[3]. Helena Van Overloop, et al. Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies. J Lipid Res. 2006 Feb;47(2):268-83. [Content Brief]

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