Chorion-specific transcription factor GCMa

Definition:

Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development.

References:

[1]. K Yamada, et al. A GCM motif protein is involved in placenta-specific expression of human aromatase gene. J Biol Chem. 1999 Nov 5;274(45):32279-86. [Content Brief]

[2]. Miao Chang, et al. Glial cell missing 1 regulates placental growth factor (PGF) gene transcription in human trophoblast. Biol Reprod. 2008 May;78(5):841-51. [Content Brief]

[3]. D Baczyk, et al. Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast. Cell Death Differ. 2009 May;16(5):719-27. [Content Brief]

[4]. Hsiao-Fan Lo, et al. Association of dysfunctional synapse defective 1 (SYDE1) with restricted fetal growth - SYDE1 regulates placental cell migration and invasion. J Pathol. 2017 Feb;241(3):324-336. [Content Brief]

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