Chromatin immunoprecipitation (ChIP)

Definition:

Chromatin immunoprecipitation (ChIP) is a technique whereby a protein of interest is selectively immunoprecipitated from a chromatin preparation to determine the DNA sequences associated with it. ChIP has been widely used to map the localization of post-translationally modified histones, histone variants, transcription factors, or chromatin modifying enzymes on the genome or on a given locus.

References:

[1]. Philippe Collas, et al. The current state of chromatin immunoprecipitation. Mol Biotechnol. 2010 May;45(1):87-100. [Content Brief]

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