Chromosome-associated kinesin KIF4A

Definition:

Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis. Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity).

References:

[1]. Yasuhiro Kurasawa, et al. Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. EMBO J. 2004 Aug 18;23(16):3237-48. [Content Brief]

[2]. Lilach Ben-Shimon, et al. Fe-S cluster coordination of the chromokinesin KIF4A alters its subcellular localization during mitosis. J Cell Sci. 2018 Jun 27;131(12):jcs211433. [Content Brief]

[3]. Changjun Zhu, et al. Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):343-8. [Content Brief]

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