Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial

Definition:

Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria. Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methyl group per binding event.

References:

[1]. Virginie F Rhein, et al. Human METTL12 is a mitochondrial methyltransferase that modifies citrate synthase. FEBS Lett. 2017 Jun;591(12):1641-1652. [Content Brief]

[2]. Jędrzej Małecki, et al. Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation. J Biol Chem. 2017 Oct 27;292(43):17950-17962. [Content Brief]

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