Complement C1r subcomponent-like protein

Definition:

Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.

References:

[1]. Christina Ligoudistianou, et al. A novel human complement-related protein, C1r-like protease (C1r-LP), specifically cleaves pro-C1s. Biochem J. 2005 Apr 1;387(Pt 1):165-73. [Content Brief]

[2]. Naisong Lin, et al. A novel human dendritic cell-derived C1r-like serine protease analog inhibits complement-mediated cytotoxicity. Biochem Biophys Res Commun. 2004 Aug 20;321(2):329-36. [Content Brief]

[3]. Krzysztof B Wicher, et al. Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein. Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14390-5. [Content Brief]

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