Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b]

Definition:

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.

References:

[1]. R G DiScipio, et al. The architecture of complement component C9 and poly(C9). J Biol Chem. 1985 Nov 25;260(27):14802-9. [Content Brief]

[2]. K Witzel-Schlömp, et al. Heterogeneity in the genetic basis of human complement C9 deficiency. Immunogenetics. 1998 Jul;48(2):144-7. [Content Brief]

[3]. Natalya V Dudkina, et al. Structure of the poly-C9 component of the complement membrane attack complex. Nat Commun. 2016 Feb 4;7:10588. [Content Brief]

[4]. Bradley A Spicer, et al. The first transmembrane region of complement component-9 acts as a brake on its self-assembly. Nat Commun. 2018 Aug 15;9(1):3266. [Content Brief]

[5]. H A Lassiter, et al. The administration of complement component C9 enhances the survival of neonatal rats with Escherichia coli sepsis. Pediatr Res. 1997 Jul;42(1):128-36. [Content Brief]

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