Cyclin-dependent kinase 11B

Definition:

Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.

References:

[1]. Dongli Hu, et al. CDK11 complexes promote pre-mRNA splicing. J Biol Chem. 2003 Mar 7;278(10):8623-9. [Content Brief]

[2]. B A Bunnell, et al. Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7467-71. [Content Brief]

[3]. Pascal Loyer, et al. Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection. J Biol Chem. 2008 Mar 21;283(12):7721-32. [Content Brief]

[4]. She Chen, et al. The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis. J Biol Chem. 2003 May 30;278(22):20029-36. [Content Brief]

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