Cyclophilin A (CypA)

Definition:

Cyclophilin A (CypA), a key member of the immunophilin family, is the most abundantly expressed isozyme of the 18 known human cyclophilins. Besides acting as an intracellular receptor for cyclosporine A, CypA plays a vital role in microorganismal infections, cardiovascular diseases, liver diseases, kidney diseases, neurodegeneration, cancer, rheumatoid arthritis, periodontitis, sepsis, asthma, and aging.

References:

[1]. Liao Y, et al. Cyclophilin A: a key player for etiological agent infection. Appl Microbiol Biotechnol. 2021 Feb;105(4):1365-1377. [Content Brief]

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