Cytoplasmic FMR1-interacting protein 2

Definition:

Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).

References:

[1]. E Saller, et al. Increased apoptosis induction by 121F mutant p53. EMBO J. 1999 Aug 16;18(16):4424-37. [Content Brief]

[2]. Roger S Jackson 2nd, et al. CYFIP2, a direct p53 target, is leptomycin-B sensitive. Cell Cycle. 2007 Jan 1;6(1):95-103. [Content Brief]

[3]. Michael Mayne, et al. CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion. Eur J Immunol. 2004 Apr;34(4):1217-27. [Content Brief]

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