Cytosolic 5'-nucleotidase 1A

Definition:

Catalyzes the hydrolysis of ribonucleotide and deoxyribonucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside. AMP is the major substrate but can also hydrolyze dCMP and IMP.

References:

[1]. A C Skladanowski, et al. Soluble forms of 5'-nucleotidase in rat and human heart. Am J Physiol. 1996 Apr;270(4 Pt 2):H1493-500. [Content Brief]

[2]. M Tavenier, et al. Kinetics of adenylate metabolism in human and rat myocardium. Biochim Biophys Acta. 1995 Jun 9;1244(2-3):351-6. [Content Brief]

[3]. S A Hunsucker, et al. Human cytosolic 5'-nucleotidase I: characterization and role in nucleoside analog resistance. J Biol Chem. 2001 Mar 30;276(13):10498-504. [Content Brief]

[4]. Agata Jędrzejewska, et al. The decreased serum activity of cytosolic 5'-nucleotidase IA as a potential marker of breast cancer-associated muscle inflammation. Nucleosides Nucleotides Nucleic Acids. 2022;41(3):273-284. [Content Brief]

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