Cytosolic iron-sulfur assembly component 2B

Definition

Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis.

References:

[1]. Kerstin Gari, et al. MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. Science. 2012 Jul 13;337(6091):243-5. [Content Brief]

[2]. Shinsuke Ito, et al. MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation. Mol Cell. 2010 Aug 27;39(4):632-40. [Content Brief]

[3]. Oliver Stehling, et al. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. Science. 2012 Jul 13;337(6091):195-9. [Content Brief]

[4]. Lilach Ben-Shimon, et al. Fe-S cluster coordination of the chromokinesin KIF4A alters its subcellular localization during mitosis. J Cell Sci. 2018 Jun 27;131(12):jcs211433. [Content Brief]

[5]. Oliver Stehling, et al. Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. Cell Metab. 2013 Aug 6;18(2):187-98. [Content Brief]

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