Cytotoxic T-lymphocyte protein 4

Definition:

Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

References:

[1]. Wendy A Teft, et al. A molecular perspective of CTLA-4 function. Annu Rev Immunol. 2006;24:65-97. [Content Brief]

[2]. P S Linsley, et al. CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med. 1991 Sep 1;174(3):561-9. [Content Brief]

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