DALR anticodon-binding domain-containing protein 3

Definition:

Involved in tRNA methylation. Facilitates the recognition and targeting of tRNA(Arg)(CCU) and tRNA(Arg)(UCU) substrates for N(3)-methylcytidine modification by METTL2A and METTL2B.

References:

[1]. Jenna M Lentini, et al. DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification. Nat Commun. 2020 May 19;11(1):2510. [Content Brief]

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