Dead end protein homolog 1

Definition:

RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).

References:

[1]. Martijn Kedde, et al. RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell. 2007 Dec 28;131(7):1273-86. [Content Brief]

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