Death domain-containing protein CRADD

Definition:

Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway.

References:

[1]. H Duan, et al. RAIDD is a new 'death' adaptor molecule. Nature. 1997 Jan 2;385(6611):86-9. [Content Brief]

[2]. Hyun Ho Park, et al. Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell. 2007 Feb 9;128(3):533-46. [Content Brief]

[3]. H Vakifahmetoglu, et al. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. Oncogene. 2006 Sep 14;25(41):5683-92. [Content Brief]

[4]. Antoine Tinel, et al. The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science. 2004 May 7;304(5672):843-6. [Content Brief]

[5]. Antoine Tinel, et al. Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. EMBO J. 2007 Jan 10;26(1):197-208. [Content Brief]

[6]. M Ahmad, et al. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res. 1997 Feb 15;57(4):615-9. [Content Brief]

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