Dehydrogenase/reductase SDR family member 9

Definition:

3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. Also plays a role in the biosynthesis of retinoic acid from retinaldehyde. Can utilize both NADH and NADPH.

References:

[1]. C M Soref, et al. Characterization of a novel airway epithelial cell-specific short chain alcohol dehydrogenase/reductase gene whose expression is up-regulated by retinoids and is involved in the metabolism of retinol. J Biol Chem. 2001 Jun 29;276(26):24194-202. [Content Brief]

[2]. Nedialka G Markova, et al. Expression pattern and biochemical characteristics of a major epidermal retinol dehydrogenase. Mol Genet Metab. 2003 Feb;78(2):119-35. [Content Brief]

[3]. Michael V Fiandalo, et al. Inhibition of dihydrotestosterone synthesis in prostate cancer by combined frontdoor and backdoor pathway blockade. Oncotarget. 2018 Jan 10;9(13):11227-11242. [Content Brief]

[4]. S V Chetyrkin, et al. Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties. J Biol Chem. 2001 Jun 22;276(25):22278-86. [Content Brief]

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