Delayed sleep phase syndrome

Definition:

Delayed sleep phase syndrome (DSPS) is characterized by a 3 to 6-hour delayed sleep schedule relative to the desired. The single nucleotide polymorphism (Ala129Thr) in Arylalkylamine N-acetyltransferase (AANAT), a rate-limiting enzyme in melatonin synthesis, has been identified in patients with delayed sleep phase disorder.

References:

[1]. Alina Patke, et al. Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder. Cell. 2017 Apr 6;169(2):203-215.e13. [Content Brief]

[2]. Ana Barion, et al. Circadian rhythm sleep disorders. Dis Mon. 2011 Aug;57(8):423-37. [Content Brief]

[3]. Bjørn Bjorvatn, et al. A practical approach to circadian rhythm sleep disorders. Sleep Med Rev. 2009 Feb;13(1):47-60. [Content Brief]

[4]. Hirohiko Hohjoh, et al. Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome. Neurogenetics. 2003 Apr;4(3):151-3. [Content Brief]

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