DENN domain-containing protein 2B

Definition:

[Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane.; [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.; [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable).

References:

[1]. Shin-ichiro Yoshimura, et al. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. J Cell Biol. 2010 Oct 18;191(2):367-81. [Content Brief]

[2]. M Majidi, et al. Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5. J Biol Chem. 1998 Jun 26;273(26):16608-14. [Content Brief]

[3]. A E Hubbs, et al. Expression of an isoform of the novel signal transduction protein ST5 is linked to cell morphology. Oncogene. 1999 Apr 15;18(15):2519-25. [Content Brief]

[4]. Maria S Ioannou, et al. Intersectin-s interaction with DENND2B facilitates recycling of epidermal growth factor receptor. EMBO Rep. 2017 Dec;18(12):2119-2130. [Content Brief]

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