Deoxycytidine kinase

Definition:

Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine. Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

References:

[1]. Elisabetta Sabini, et al. Structural basis for substrate promiscuity of dCK. J Mol Biol. 2008 May 2;378(3):607-21. [Content Brief]

[2]. E G Chottiner, et al. Cloning and expression of human deoxycytidine kinase cDNA. Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1531-5. [Content Brief]

[3]. Elisabetta Sabini, et al. Structure of human dCK suggests strategies to improve anticancer and antiviral therapy. Nat Struct Biol. 2003 Jul;10(7):513-9. [Content Brief]

[4]. Saugata Hazra, et al. Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase. Biochemistry. 2009 Feb 17;48(6):1256-63. [Content Brief]

[5]. Saugata Hazra, et al. Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues. Biochemistry. 2010 Aug 10;49(31):6784-90. [Content Brief]

[6]. Caroline Smal, et al. Casein kinase 1delta activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity. Arch Biochem Biophys. 2010 Oct 1;502(1):44-52. [Content Brief]

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