Deoxyribonuclease-2-beta

Definition:

Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation.

References:

[1]. Sogo Nishimoto, et al. Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens. Nature. 2003 Aug 28;424(6952):1071-4. [Content Brief]

[2]. D Shiokawa, et al. Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase. Biochem Biophys Res Commun. 2001 Nov 16;288(5):1119-28. [Content Brief]

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