Deubiquitinase OTUD6B

Definition:

[Isoform 1]: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1. May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation. May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation. May also play a role in proteasome assembly and function.; [Isoform 2]: Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability.

References:

[1]. Anna Sobol, et al. Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation. Mol Cancer Res. 2017 Feb;15(2):117-127. [Content Brief]

[2]. Zhongping Xu, et al. Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation. PLoS One. 2011 Jan 18;6(1):e14514. [Content Brief]

[3]. Teresa Santiago-Sim, et al. Biallelic Variants in OTUD6B Cause an Intellectual Disability Syndrome Associated with Seizures and Dysmorphic Features. Am J Hum Genet. 2017 Apr 6;100(4):676-688. [Content Brief]

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