Dihydropyrimidine dehydrogenase (DPD)

Definition:

Dihydropyrimidine dehydrogenase (DPD) is an enzyme majorly involved in the metabolism of pyrimidines in the human body and has the same metabolising effect on 5-FU, a pyrimidine analogue.

References:

[1]. Sharma V, et al. Dihydropyrimidine dehydrogenase in the metabolism of the anticancer drugs. Cancer Chemother Pharmacol. 2019 Dec;84(6):1157-1166. [Content Brief]

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