Diphthine methyltransferase

Definition:

Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).

References:

[1]. Jan E Carette, et al. Haploid genetic screens in human cells identify host factors used by pathogens. Science. 2009 Nov 27;326(5957):1231-5. [Content Brief]

[2]. Hui Wei, et al. A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene. J Biol Chem. 2013 Apr 26;288(17):12305-12. [Content Brief]

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