Disintegrin and metalloproteinase domain-containing protein 15

Definition:

Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.

References:

[1]. John Martin, et al. The role of ADAM 15 in glomerular mesangial cell migration. J Biol Chem. 2002 Sep 13;277(37):33683-9. [Content Brief]

[2]. Abdo J Najy, et al. The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation. J Biol Chem. 2008 Jun 27;283(26):18393-401. [Content Brief]

[3]. Dong Lu, et al. Inhibition of airway smooth muscle adhesion and migration by the disintegrin domain of ADAM-15. Am J Respir Cell Mol Biol. 2007 Oct;37(4):494-500. [Content Brief]

[4]. Beate B Böhm, et al. Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling. Arthritis Rheum. 2005 Apr;52(4):1100-9. [Content Brief]

[5]. Laetitia Charrier, et al. ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers. Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G346-53. [Content Brief]

[6]. Qin Chen, et al. ADAM15 suppresses cell motility by driving integrin alpha5beta1 cell surface expression via Erk inactivation. Int J Biochem Cell Biol. 2008;40(10):2164-73. [Content Brief]

[7]. Laetitia Charrier, et al. ADAM-15/metargidin mediates homotypic aggregation of human T lymphocytes and heterotypic interactions of T lymphocytes with intestinal epithelial cells. J Biol Chem. 2007 Jun 8;282(23):16948-58. [Content Brief]

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