DNA damage-inducible transcript 4 protein
Definition:
References:
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[1]. Cristina Malagelada, et al. RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation. J Neurosci. 2006 Sep 27;26(39):9996-10005. [Content Brief]
[2]. Avi Sofer, et al. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol. 2005 Jul;25(14):5834-45. [Content Brief]
[3]. H-O Jin, et al. TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1. Oncogene. 2011 Sep 1;30(35):3792-801. [Content Brief]
[4]. Sigal Gery, et al. RTP801 is a novel retinoic acid-responsive gene associated with myeloid differentiation. Exp Hematol. 2007 Apr;35(4):572-8. [Content Brief]
[5]. Samiksha Katiyar, et al. REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase. EMBO Rep. 2009 Aug;10(8):866-72. [Content Brief]
[6]. Silvia Vega-Rubin-de-Celis, et al. Structural analysis and functional implications of the negative mTORC1 regulator REDD1. Biochemistry. 2010 Mar 23;49(11):2491-501. [Content Brief]
[7]. James Brugarolas, et al. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 2004 Dec 1;18(23):2893-904. [Content Brief]
[8]. Michael N Corradetti, et al. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem. 2005 Mar 18;280(11):9769-72. [Content Brief]
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