DNA excision repair protein ERCC-6-like

Definition:

DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).

References:

[1]. Andreas Biebricher, et al. PICH: a DNA translocase specially adapted for processing anaphase bridge DNA. Mol Cell. 2013 Sep 12;51(5):691-701. [Content Brief]

[2]. Ganesha P Pitchai, et al. A novel TPR-BEN domain interaction mediates PICH-BEND3 association. Nucleic Acids Res. 2017 Nov 2;45(19):11413-11424. [Content Brief]

[3]. Christoph Baumann, et al. PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint. Cell. 2007 Jan 12;128(1):101-14. [Content Brief]

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