DNA repair and recombination protein RAD54-like

Definition:

Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity).

References:

[1]. Stefan Sigurdsson, et al. Homologous DNA pairing by human recombination factors Rad51 and Rad54. J Biol Chem. 2002 Nov 8;277(45):42790-4. [Content Brief]

[2]. Julian Spies, et al. Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability. Mol Cell. 2016 Jun 16;62(6):903-917. [Content Brief]

[3]. S M Swagemakers, et al. The human RAD54 recombinational DNA repair protein is a double-stranded DNA-dependent ATPase. J Biol Chem. 1998 Oct 23;273(43):28292-7. [Content Brief]

[4]. Shinichi Machida, et al. Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1. Sci Rep. 2014 May 6;4:4863. [Content Brief]

[5]. D Ristic, et al. The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8454-60. [Content Brief]

[6]. Qin Zhou, et al. The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair. Nat Commun. 2020 May 26;11(1):2639. [Content Brief]

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