DNA repair protein XRCC1
Definition:
References:
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[1]. Annie A Demin, et al. XRCC1 prevents toxic PARP1 trapping during DNA base excision repair. Mol Cell. 2021 Jul 15;81(14):3018-3030.e5. [Content Brief]
[2]. Nicolas C Hoch, et al. XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. Nature. 2017 Jan 5;541(7635):87-91. [Content Brief]
[3]. Marek Adamowicz, et al. XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair. Nat Cell Biol. 2021 Dec;23(12):1287-1298. [Content Brief]
[4]. C J Whitehouse, et al. XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell. 2001 Jan 12;104(1):107-17. [Content Brief]
[5]. Sherif F El-Khamisy, et al. A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. Nucleic Acids Res. 2003 Oct 1;31(19):5526-33. [Content Brief]
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