DNA replication factor Cdt1

Definition:

Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC). Required also for mitosis by promoting stable kinetochore-microtubule attachments. Potential oncogene (By similarity).

References:

[1]. J A Wohlschlegel, et al. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science. 2000 Dec 22;290(5500):2309-12. [Content Brief]

[2]. André Franz, et al. Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun. 2016 Feb 4;7:10612. [Content Brief]

[3]. Jeanette Gowen Cook, et al. The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells. J Biol Chem. 2004 Mar 5;279(10):9625-33. [Content Brief]

[4]. Nozomi Sugimoto, et al. Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. J Biol Chem. 2004 May 7;279(19):19691-7. [Content Brief]

[5]. Benoit Miotto, et al. JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. Mol Cell. 2011 Oct 7;44(1):62-71. [Content Brief]

[6]. Dileep Varma, et al. Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment. Nat Cell Biol. 2012 May 13;14(6):593-603. [Content Brief]

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