DNA topoisomerase 2-beta

Definition:

Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation.

References:

[1]. Olivier Papapietro, et al. Topoisomerase 2β mutation impairs early B-cell development. Blood. 2020 Apr 23;135(17):1497-1501. [Content Brief]

[2]. Lori Broderick, et al. Mutations in topoisomerase IIβ result in a B cell immunodeficiency. Nat Commun. 2019 Aug 13;10(1):3644. [Content Brief]

[3]. K L West, et al. Mutagenesis of E477 or K505 in the B' domain of human topoisomerase II beta increases the requirement for magnesium ions during strand passage. Biochemistry. 2000 Feb 15;39(6):1223-33. [Content Brief]

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