DNA topoisomerase I (topo I)

Definition:

DNA topoisomerase I is an enzyme that cuts DNA strands. The DNA relaxation activity of topoisomerase I is dispensable for transcriptional repression.

References:

[1]. Merino A, et al. DNA topoisomerase I is involved in both repression and activation of transcription. Nature. 1993 Sep 16;365(6443):227-32. [Content Brief]

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