DnaJ homolog subfamily C member 13

Definition:

Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR. Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex.

References:

[1]. Martine Girard, et al. RME-8 regulates trafficking of the epidermal growth factor receptor. FEBS Lett. 2008 Mar 19;582(6):961-6. [Content Brief]

[2]. Akemi Fujibayashi, et al. Human RME-8 is involved in membrane trafficking through early endosomes. Cell Struct Funct. 2008;33(1):35-50. [Content Brief]

[3]. Caroline L Freeman, et al. RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation. J Cell Sci. 2014 May 1;127(Pt 9):2053-70. [Content Brief]

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