Double-stranded RNA-binding protein Staufen homolog 1

Definition

Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.; (Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process.

References:

[1]. A M Falcón, et al. Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro. Nucleic Acids Res. 1999 Jun 1;27(11):2241-7. [Content Brief]

[2]. Jingru Fang, et al. Staufen1 Interacts with Multiple Components of the Ebola Virus Ribonucleoprotein and Enhances Viral RNA Synthesis. mBio. 2018 Oct 9;9(5):e01771-18. [Content Brief]

[3]. Laurent Chatel-Chaix, et al. The host protein Staufen1 interacts with the Pr55Gag zinc fingers and regulates HIV-1 assembly via its N-terminus. Retrovirology. 2008 May 22;5:41. [Content Brief]

[4]. Kirsten Hanke, et al. Staufen-1 interacts with the human endogenous retrovirus family HERV-K(HML-2) rec and gag proteins and increases virion production. J Virol. 2013 Oct;87(20):11019-30. [Content Brief]

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