Dual serine/threonine and tyrosine protein kinase

Definition:

Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.

References:

[1]. Jikun Zha, et al. RIP5 is a RIP-homologous inducer of cell death. Biochem Biophys Res Commun. 2004 Jun 25;319(2):298-303. [Content Brief]

[2]. Simone Sanna-Cherchi, et al. Mutations in DSTYK and dominant urinary tract malformations. N Engl J Med. 2013 Aug 15;369(7):621-9. [Content Brief]

[3]. John Y W Lee, et al. Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23. Am J Hum Genet. 2017 Feb 2;100(2):364-370. [Content Brief]

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