Dual specificity protein phosphatase 18

Definition:

Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).

References:

[1]. Kristin L Hood, et al. Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. Biochem Biophys Res Commun. 2002 Nov 8;298(4):545-51. [Content Brief]

[2]. Qihan Wu, et al. Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain. Biochim Biophys Acta. 2003 Feb 20;1625(3):296-304. [Content Brief]

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