Dynamin-binding protein

Definition:

Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells. Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation. Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).

References:

[1]. Tetsuhisa Otani, et al. Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells. J Cell Biol. 2006 Oct 9;175(1):135-46. [Content Brief]

[2]. Yi Qin, et al. Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation. J Cell Biol. 2010 May 17;189(4):661-9. [Content Brief]

[3]. Tina Rajabian, et al. The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria. Nat Cell Biol. 2009 Oct;11(10):1212-8. [Content Brief]

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