E3 ubiquitin-protein ligase DZIP3

Definition:

E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.

References:

[1]. Stefan G Kreft, et al. hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase. J Cell Sci. 2003 Feb 15;116(Pt 4):605-16. [Content Brief]

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