E3 ubiquitin-protein ligase NEDD4

[1]. Xinjiang Wang, et al. NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell. 2007 Jan 12;128(1):129-39. [Content Brief]

[2]. Elena Maspero, et al. Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation. EMBO Rep. 2011 Apr;12(4):342-9. [Content Brief]

[3]. Avinash Persaud, et al. Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. EMBO J. 2011 Jul 15;30(16):3259-73. [Content Brief]

[4]. Joanna Timmins, et al. Ebola virus matrix protein VP40 interaction with human cellular factors Tsg101 and Nedd4. J Mol Biol. 2003 Feb 14;326(2):493-502. [Content Brief]

[5]. N Pham, et al. Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF. J Biol Chem. 2001 Dec 14;276(50):46995-7003. [Content Brief]

[6]. Elena Maspero, et al. Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming. Nat Struct Mol Biol. 2013 Jun;20(6):696-701. [Content Brief]

[7]. Michelle Harreman, et al. Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20705-10. [Content Brief]

[8]. M H Hamilton, et al. Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. J Biol Chem. 2001 Jul 13;276(28):26324-31. [Content Brief]

[9]. Fatemeh Fouladkou, et al. The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization. Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8585-90. [Content Brief]

[10]. Atsushi Okumura, et al. ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3974-9. [Content Brief]

[11]. Qiong Lin, et al. HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. Mol Cell Biol. 2010 Mar;30(6):1541-54. [Content Brief]

[12]. Ley-Hian Low, et al. Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response. J Biol Chem. 2015 Mar 13;290(11):7141-50. [Content Brief]