E3 ubiquitin-protein ligase RNF125

Definition:

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation.

References:

[1]. Qian Hao, et al. A non-canonical role of the p97 complex in RIG-I antiviral signaling. EMBO J. 2015 Dec 2;34(23):2903-20. [Content Brief]

[2]. Liuzhong Yang, et al. RNF125 is a ubiquitin-protein ligase that promotes p53 degradation. Cell Physiol Biochem. 2015;35(1):237-45. [Content Brief]

[3]. Haoran Zhao, et al. A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation. J Immunol. 2005 May 1;174(9):5288-97. [Content Brief]

[4]. Marie-José Bijlmakers, et al. A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125. Sci Rep. 2016 Jul 14;6:29232. [Content Brief]

[5]. Kei-ichiro Arimoto, et al. Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7500-5. [Content Brief]

[6]. Hyungsoo Kim, et al. Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation. Cell Rep. 2015 Jun 9;11(9):1458-73. [Content Brief]

[7]. Sanae Shoji-Kawata, et al. The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells. Virology. 2007 Nov 10;368(1):191-204. [Content Brief]

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