E3 ubiquitin-protein ligase RNF139

[1]. Masato Irisawa, et al. The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage. J Biol Chem. 2009 Oct 16;284(42):28995-9004. [Content Brief]

[2]. Helen R Stagg, et al. The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER. J Cell Biol. 2009 Sep 7;186(5):685-92. [Content Brief]

[3]. K L Lorick, et al. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11364-9. [Content Brief]

[4]. A Brauweiler, et al. RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. Oncogene. 2007 Apr 5;26(16):2263-71. [Content Brief]

[5]. Jason P Lee, et al. The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways. Mol Cancer Res. 2010 Jan;8(1):93-106. [Content Brief]

[6]. Robert M Gemmill, et al. The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. Oncogene. 2002 May 16;21(22):3507-16. [Content Brief]

[7]. Youngah Jo, et al. Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20503-8. [Content Brief]

[8]. Youngah Jo, et al. Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes. Mol Biol Cell. 2013 Feb;24(3):169-83. [Content Brief]