1. Biology Dictionary
  2. E3 ubiquitin-protein ligase RNFT1

E3 ubiquitin-protein ligase RNFT1

Definition:

E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis.

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