E3 ubiquitin-protein ligase TM129

Definition:

E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.

References:

[1]. Michael L van de Weijer, et al. A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. Nat Commun. 2014 May 8;5:3832. [Content Brief]

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