E3 ubiquitin-protein ligase TRIM69

Definition:

E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection. Plays also a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination.

References:

[1]. Suzannah J Rihn, et al. TRIM69 Inhibits Vesicular Stomatitis Indiana Virus. J Virol. 2019 Sep 30;93(20):e00951-19. [Content Brief]

[2]. Xianfang Rong, et al. TRIM69 inhibits cataractogenesis by negatively regulating p53. Redox Biol. 2019 Apr;22:101157. [Content Brief]

[3]. Tonya Kueck, et al. Vesicular Stomatitis Virus Transcription Is Inhibited by TRIM69 in the Interferon-Induced Antiviral State. J Virol. 2019 Nov 26;93(24):e01372-19. [Content Brief]

[4]. Kezhen Wang, et al. Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3. PLoS Pathog. 2018 Aug 24;14(8):e1007287. [Content Brief]

[5]. Yongqing Han, et al. Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation. Biochem Biophys Res Commun. 2012 Dec 7;429(1-2):6-11. [Content Brief]

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