EGF-containing fibulin-like extracellular matrix protein 1

Definition:

Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.

References:

[1]. Toru Wakabayashi, et al. Fibulin-3 negatively regulates chondrocyte differentiation. Biochem Biophys Res Commun. 2010 Jan 1;391(1):1116-21. [Content Brief]

[2]. Peter Camaj, et al. EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells. Biol Chem. 2009 Dec;390(12):1293-302. [Content Brief]

[3]. Bin Hu, et al. Fibulin-3 is uniquely upregulated in malignant gliomas and promotes tumor cell motility and invasion. Mol Cancer Res. 2009 Nov;7(11):1756-70. [Content Brief]

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